Say, you don't know what combinations to use, you have no system. Do this: Play all combinations from second column of Pick 3 list of winning numbers. You'll spend 50 Straight tickets, or Box tickets, and might have a hit and win $500 or a Box $80. Odds are a lot more beneficial than 1/1000. At best it 's going to be 1/10 chance or 1/50 and also can be worse.

Well, per game you'd have to spend 7 tickets per combination, 1 Box and 6 Straights, if you multiply  50 combinations by 7, you'll have to get $350 tickets to may be, at best win $580. Or you can loose in most cases.

Or, you can buy just 50 Box tickets and win $80, or loose. Whichever way is more affordable or safe for you, you can use. Game remains to be game, only with more beneficial odds.

If smaller odds scare you, then you, probably, should not play lottery at all.