https://pmc.ncbi.nlm.nih.gov/articles/PMC5696016/    Part of article. 

Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP is capable of causing dose-related hepatocellular necrosis, responsible for nearly 500 deaths annually in the U.S. alone, as well as 100,000 calls to US Poison Control Centers, 50,000 emergency room visits and 10,000 hospitalizations per year. As an over-the-counter and prescription product (with opioids), APAP toxicity dwarfs all other prescription drugs as a cause for acute liver failure in the United States and Europe, but is not regulated in any significant way. 

Acetaminophen (N-acetyl-p-aminophenol, APAP, paracetamol, Tylenol^®) is a ubiquitous and highly utilized over-the-counter medication for relief of pain and fever that is also a dose-related toxin.¹ APAP toxicity accounts for 46% of all acute liver failure (ALF) in the United States² and between 40 and 70% of all cases in Great Britain and Europe.³ Acetaminophen toxicity dwarfs by several-fold the number of deaths related to acute liver failure (ALF) resulting from all prescription drugs combined (Figure 1), and has been the subject of two United States Food and Drug Administration (FDA) Advisory Committee meetings in the past 15 years.

History

As early as 1960, paracetamol, as it is referred to in Europe and the United Kingdom (UK), had become a popular analgesic for the treatment of headache and mild pain, possessing few of the side effects associated with aspirin (acetylsalicylic acid, ASA). By 1966, reports began to appear concerning its association with liver injury resulting in fatal outcomes. By the 1970's, paracetamol was the most frequently used suicidal agent⁷ in the UK; the Liver Unit at Kings College Hospital London, in 1972 set up the first 2-bed Liver Failure Intensive Care Unit, typically filled with young women on life support following attempts at self-harm. A single-time-point APAP overdose of 12-15 grams (24-30 ‘extra strength’ (500 mg) tablets), is associated with an approximately 50% mortality.

And for those that weren't around in 1982, it is also the reason why we now have tamper resistant packaging.

https://en.wikipedia.org/wiki/Chicago_Tylenol_murders