I've seen this discussed here before: if you're buying 50+ tickets for Mega Millions or Powerball, why not just buy ever possible megaball/powerball number?
As a caveat, I never look for patterns in old numbers drawn, and assume that numbers are chosen randomly. I know that this isn't exactly true, but I've decided it's not worth hours and hours of my time to do analysis that might give me an infintesimal advantage.
I live just outside Boston. I can play mega millions at my corner store, so I do. I usually play quick picks, unless I'm buying 50+ tickets, in which case I use my computer to sort the tickets by megaball number. Still use an RNG, though.
But when I play Powerball, I have to drive 30 miles to New Hampshire. So I don't really want to win 3 frigging bucks. I buy 30 tickets with the same powerball so if I win, I win at least $90, and if I lose, I don;t have to make an extra trip to NH. If I've got a big pool, I put all of the money on three powerballs (equally distributed) so that we either make money, break even, or lose everything. When someone gives you $20 for a pool, you feel dumb giving them $1 the next day.