The pick-5 numbers are sorted from lowest to highest on the tickets. Positional limits create cause and effect. If 5 must be in the first position or the lowest number, 1, 2, 3, and 4 can't be drawn and for 5 to be in the second position, one of those numbers must be drawn. The same is true if you decide that 35 must be in the 5th position; there is no reason to consider any number higher than 35.
Positional limits can be used as filters in full wheels but if you use them with abbreviated wheels, you're risking losing your win guarantee. Abbreviated wheels mathematically place the amount of numbers in an order. In a wheel like a 3if4of16, you could enter the numbers 1-16 and check the distribution and check where you could place the number 5 so if does hit, it would be in the first or second position.
The more numbers you have that must be in certain positions creates a cause and effect too so it might take a while until you get all of your numbers into the correct positions. It depends on the type and size of the wheel.