Don't mind the wise crack answers because even though some members have nothing useful to contribute, they still find it necessary to say something; probably just to pad their post counts.
Advantage Plus is like most analytical software and gives you hundreds of ways to find the "best" numbers. Since you mentioned 27 numbers, the trick is finding a group of numbers that consistently matches 6 numbers because a 4 if 6 of 27 numbers wheel has 243 combos. You'll need at least four 4 number matches to cover the cost of play so the one 4 number match isn't near enough. That program offers "Smart Picks" and a screen to view the past performance of "Smart Picks" to see how many of those 27 number groups consistently has 6 number matches.
A full 27 number wheel has 296,010 combos so even consistently matching 6 numbers gives you less than 1% chance of winning a jackpot using an abbreviated 4 if 6 wheel. The program has zone and conditional wheels with better win guarantees when matching all 6 and your lottery budget will dictate which one to use. Good luck!
I also found an interesting article questioning the 106 jackpot wins worth $101.5 million claimed on Gail Howard's website.
"A New Jersey member of the lottery chat room, Lottery Post Forum, found it impossible to believe that Gail Howard has all these jackpot winners, so he assumed it was not true -- not bothering to check out her web site. He stated on Lottery Post: "Anyone who is selling software with that claim is scamming you. If it worked so well, they wouldn't sell it; they would simply keep winning lotteries and keeping the money. That's what I would do, and if you think about it, so would you." This is the typical attitude of selfish people who view others through their own inadequacies."