About the Big4, there are only 10,000 combos (straight) and there are 2,620 that have NEVER been drawn, ever, since 1980 which the first Big4 draw was held. If you want to narrow it down to some box hits that have never been drawn, in ANY order, there are only two. 2226 and 4445. The only QUADs never drawn are 0000, 6666, 9999. So maybe play 2226 and 4445 for a cool $600 per 0.50 or a cool $2500 for a QUAD.
The 3 digit on the other hand has seen all 1,000 possible straight hits and every box combo has been drawn as well. So maybe try something like playing the least and most drawn, or somehting in the middle as well.
The most drawn straight number is 120 (eve and mid mix included)
254 and 398 have been equally drawn the least amount of times, straight, which is 5 times (eve and mid included)
These ones have been drawn the most in a box order: 015 for singles and 177 for a double.
If you want a long shot (box) then 038 has not been drawn in any order for nine hundred and ninety three draws.
and 455 for a double has not been seen in any order for one thousand eight hundred and seventy two draws!!
Of the above numbers, if you want to compute some midday numbers and try to figure out if any computer has anything to do with any draw, then your best bet would just be to box the most drawn and maybe include the least as well. As you and I know, anything can happen and 777 could come out 7 draws in a row. It's all up to Gus (is he in a retirement home now?)