Okay… here goes….
You gotta just go with something sometimes, right? And according to my own analytical brew, it is overwhelmingly likely a 5, 9, or 1 will play in the next draw—if one doesn't, it will be the first time in about a year that this kind of thing has happened (or longer: I'm only going back that far using my own methods). I feel like I've seen every possibility under the sun put into play this past year… but this will be the first this glitch has appeared. Hey, the game's known for doing things like that! But again, you just gotta pick something and go with it sometimes.
So: I'm starting with there being at least one 5, 9, or 1 in the next draw.
Based on that and using CaLady's breakdown above (I'd do my own, but I'm just going to go with your guys' amazing picks for the time being), four boxes look great to me: 235, 176, 839, and 198. 235 and 198 seem best: they're, again, in this band of numbers I said took so long to play, and that tends to bounce back rather quickly after being played once (the last one played was 237, 13 plays back).
But I see a double just as easily… and I'm sticking to 6 (a due due due double)… and so, thusly, 61, 65 and 69 boxes are my only possibilities (despite 67 and 63 and [slightly less so] 64 being so tempting). 61 I still feel is overplayed, so… reluctantly shying away from it. The 69 appears on the 22 breakdown, so that one I lean to slightly more than the 65.
So… those are my 4 + 2/4 posits.
Gosh—I hope the lottery guys aren't reading this post and adjusting accordingly!!!