The odds for PA Pick-2 is 1 in 100, and it's a struggle to win $50 on that. Powerball at 1 in ~292 million is ~2.9 million times more difficult.
To put it another way, the entire population of California (~39 million) could each buy a ticket, and yet still only a 1 in 7 chance of hitting the jackpot.
While such a large purchase would likely yield some 2nd and 3rd tier winners, a smaller sub-set may not. I regularly check PA Lottery detailed results for Powerball, and there are drawings in which the top base prize (without Powerplay) won in all of Pennsylvania is $100. For the entire state! And I'm not talking right after reset either. Even for super large jackpots. PA Lottery payout detail for Dec-26th when the advertised jackpot was $255 million - http://www.palottery.state.pa.us/Payouts.aspx?id=54573
12/26/15
Winning Numbers: 27 40 44 59 65
Powerball: 20 Power Play: 02
0 PA winners, jackpot rolls to $300,000,000.00
0 PA players matched 5 of 5, each receiving $1,000,000.00
0 PA players matched 4 of 5 and the Powerball, each receiving $50,000.00
22 PA players matched 4 of 5, each receiving $100.00
90 PA players matched 3 of 5 and the Powerball, each receiving $100.00
1,886 PA players matched 3 of 5, each receiving $7.00
1,658 PA players matched 2 of 5 and the Powerball, each receiving $7.00
12,569 PA players matched 1 of 5 and the Powerball, each receiving $4.00
31,705 PA players matched the Powerball, each receiving $4.00
Power Play:
0 PA players matched 5 of 5 and purchased Power Play, each receiving $2,000,000.00
0 PA players matched 4 of 5, the Powerball, and purchased Power Play, each receiving $100,000.00
5 PA players matched 4 of 5 and purchased Power Play, each receiving $200.00
22 PA players matched 3 of 5, the Powerball, and purchased Power Play, each receiving $200.00
502 PA players matched 3 of 5, and purchased Power Play, each receiving $14.00
392 PA players matched 2 of 5, the Powerball, and purchased Power Play, each receiving $14.00
3,185 PA players matched 1 of 5, the Powerball, and purchased Power Play, each receiving $8.00
8,185 PA players matched the Powerball and purchased Power Play, each receiving $8.00
So while it's worth being in the game, buying a million tickets (likely more than that sold for Dec-26 drawing in PA with no 2nd nor 3rd tier PA winners) or just one ticket makes relatively little difference given the insane odds of the game. Even hitting the 2nd tier prize is insanely difficult, since the matrix change. In short, don't bet the ranch on it. There are better ways to wager heavy - payout won't be record-breaking, but neither will the losses.