If you make it into 3 games of 2 digits each and then you filter pairs out for each game of 2 digits you are left with so many pairs for each of the 3 games and then maybe you need a way to combine them into pick 4 numbers, for example if you made the pick 4 into 2 games of 2 digits each, like front (Lth) and back (Rth) pairs:
California (CA) Daily 4
Fri, Sep 23, 2016 6-9 9-8
Thu, Sep 22, 2016 7-2 6-0
Wed, Sep 21, 2016 5-7 0-8
Tue, Sep 20, 2016 8-5 5-2
Mon, Sep 19, 2016 3-8 2-8
Sun, Sep 18, 2016 3-5 9-3
Sat, Sep 17, 2016 6-9 5-6
Fri, Sep 16, 2016 6-6 4-2
Thu, Sep 15, 2016 8-7 5-1
Wed, Sep 14, 2016 6-5 7-4
Etc.
After filtration or whatever you would be left with 2 vertical sets of pairs, for example:
20 88
22 99
16 72
65 35
04 11
83 65
34 50
93 58
95 71
67 99
16 58
14 37
28 45
22 13
94 62
03 14
04 01
95 52
81 72
Now you might need to combine them into pick 4 numbers, as an example:
2088 2099 2072 2035 2011 2065 Etc
2288 2299 2272 2235 Etc
1688 1699 1672 1635 Etc
Etc.
That does make for a lot of pick 4 numbers.
If you do make it into 3 or more games of 2 digits each, first filter and or predict pairs for each game of 2 digits and then combine the results into pick 4 numbers you can reduce the produced pick 4 numbers some, the more 2 digits games that you make the pick 4 game into the more that you can reduce the produced-combined numbers.
But you might need software to make the sets of pairs into pick 4 numbers as that can be very hard to do "by hand" without special software.
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0123
01 02 03 12 13 23
I made the 0123 pick 4 number into 6 pairs, using all 6 pairs would reduce the produced pick 4 numbers as much as possible.
As to the filtration or prediction for each of the 6 sets, well each person would have his or her own particular way(s) of doing that.
Each set has 100 straight pairs and you want to end-up with as few pairs as possible for each of the 6 sets or positions and once that is done you want to combine them into pick 4 numbers, that probably does need special software for doing it.
The filtrations and or prediction of each set of pairs might also be better done with special software made just for it.