I've mentioned the wheels by Steve Player and Gail Howard, these free wheels allow for low cost, 9 and 10 dollars respectfully, and can cover a wide group of numbers.  Even better is using those wheels, along with a couple KEY number wheels here. 

For low cost (below 50 bux)  I like the Pick 5 Wheel, key  3 if 3 of 9.  These create 6 plays, a dollar in OH RC 6 game, and two dollars in other states, like PA where they get 2 bux per play, and also have higher jackpots. 

So, one can use key wheels, with 10, 11, 12, at least those 3 keys combined with the Player/Howard wheels and cover the draws without a single digit as a draw nears its tipping point. 

A higher play wheel, for those wanting higher payouts and willing to spend over 100 dollars, can use the Player/Howard wheels to cover the first 3 or 4 teens which make up the bulk of the no single digit draws and then use a key 4 of 4 if 9, and play 9 numbers at a 14 dollar cost for one dollar games, or 28 for two dollar games. 

This allows a balanced coverage, and when near the tipping point, play several days in a row. In OH we win 300 dollars with 4 numbers, so I'm inclined to go 3 days in a row at that cost, hoping to recover my investment and then some. 

Whatever your strategy might be, make use of wheels to have a balanced approach to cashing in. 

These are my daily wheels, maybe you have a favorite too?  If so, feel free to share.