Angeles Crest Highway (California)
Located in the California interior, this highway heads northeast through the mountains from Los Angeles. Much of it is a two-lane road on which motorcycle and sports car drivers love to speed.

Highway 1, Florida
Carlo Allegri/Getty ImagesHighway 1 (Florida)
Outside of Key West this roadway turns into a two-lane bridge that crosses an expansive body of shallow water that reflects blinding sunlight. On top of that, "it's really tough for the driver to stay focused because everything around you is so blue," Sedenquist says. This stretch of highway is also troublesome during hurricane warnings because it is the only way out and gets packed with evacuees.

U.S. Route 50, Nevada
Scott T. Smith/Getty ImagesU.S. Route 50 (Nevada)
Called "The Loneliest Road in America" by Life in 1986, this Nevada highway is eerie because there is so little around it. "It's not uncommon for more than 30 minutes to pass before you spot another car," Dolezal says. "It brings out all those UFO and buzzard-circling fears, along with more reasonable ones about your car breaking down."

Interstate 70, Colorado
George Rose/Getty ImagesInterstate 70 (Colorado)
I-70 through Denver has one of the highest passes on all the interstates, and its steep hills can be extremely slick in the winter. In bad weather "you just stay in your lane, don't touch your brakes, and hope you make it to the bottom,"

Saddle Road, Hawaii
TMI/AlamySaddle Road (Hawaii)
Saddle Road winds through the Hualalai and Kohala Volcanoes, and much of it is comprised of only two very narrow lanes. To make things worse, some of its bridges are only one-way, meaning drivers must take turns crossing--but they don't always follow this rule.