I agree that big winners can happen on any ticket.
But I'll avoid the last few tickets of a roll whether it's 097,098,099 or 002,001,000 if they loaded it backwards. One reason is that the roll may have already had big wins on it, and the clerk and the regulars know it. So they just wait for a sucker to finish the last few tickets. I'll skip those and buy another game instead, thank you. But I don't mind buying the first few tickets of a new roll, regardless of them being high or low numbers.
I also don't think the top prizes insertion into the manufacturing and distribution is totally random. That leaves them open for lost profits if the big winners are not evenly spaced throughout the millions of tickets released for that game. There must be some pseudo-random algorithm for the big prize insertions. And as for the spacing of winners within rolls, I wouldn't put it past them to put some trickery in there as well. They obviously like to play mind games in the games themselves, trying to make you think you are close to a win or just missed it. So I would not be surprized if they manipulated the spacing and concentration of winners within rolls to have wide variances and long strings of losers. That would make it more addictive.