I'd really like to see 1,2,3,4,5 +6 or some other very popular combination come up as the winning numbers. There'd be a certain amount of humor in reading the news reports about people who told their bosses what they really think of them before finding out they shouldn't have quit their jobs, but I'd really be interested to see how many winners there would be.
Years ago (say mid-80's, maybe when quick pick was just starting?) NY ran advertisements telling people to stop playing obvious patterns on the bet slips. I forget the exact numbers, but the diagonal starting at the top left was the most common combination, and was played several thousand times in every drawing. The diagonal from the top right was the 2nd most common, with almost as many people playing it. I forget if they listed the number of plays for 1,2,3,4,5,6. Based on the number of tickets the NY lottery would have been selling compared to PB or MM I've got to assume that there would be well over 10,000 jackpot winners for 1,2,3,4,5 +6 and hundreds to thousands for any of several other combinations. The only saving grace for the diagonal combinations with PB or MM is that bet slips for different states have different layouts so there are several different combinations based on diagonals, and of course the power or mega ball isn't part of the diagonal and would further reduce the total number of 5+1 winners.
Of course there are only so many possible layouts. Without seeing slips from every state I'll guess that there are no more than 6 to 8 possibilities. Just taking a guess, if 100,000 people play the diagonal from upper left there might by between 5 and 15 thousand 5+0 winners, but no more than 1000 5+1 winners, and perhaps as few as 200. There could be 10 to 15 thousand 5+0 winners, so an actual of $1000 or less seems quite possible.
There's only one possibility for 1,2,3,4,5 +6, and I'm sure it gets played far more than just 1,000 times. Again based on that ad from the NY lottery I wouldn't be surprised if 50,000 people play it. Since an advertised jackpot of $100 million is really a cash prize of about $62 million the actual payout could be as lows as 1 to 2 grand per winner. Where it could get really interesting is in how many people play 1,2,3,4,5 and something other than 6. It's entirely possible that winning numbers of 1,2,3,4,5 +6 could result in 5+0 winners getting a better payout than 5+1 winners.
"An unlikely, but possible scenario."
Between all of the consecutive numbers, multiples of 5 or 10 and diagonals there are perhaps 100 to 125 combinations. Add in straight vertical patterns (the horizontals are already covered as consecutive), and there might be 150 obvious patterns that get played hundreds or thousands of times. With both games having just about 300 million combinations come October there's only about a 1 in 1000 chance that any of them will be drawn in the next 10 years.