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grwurston's Blog

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A Bit Of History On Tylenol For Those That Are Upset With Trump

https://pmc.ncbi.nlm.nih.gov/articles/PMC5696016/    Part of article. 

Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP is capable of causing dose-related hepatocellular necrosis, responsible for nearly 500 deaths annually in the U.S. alone, as well as 100,000 calls to US Poison Control Centers, 50,000 emergency room visits and 10,000 hospitalizations per year. As an over-the-counter and prescription product (with opioids), APAP toxicity dwarfs all other prescription drugs as a cause for acute liver failure in the United States and Europe, but is not regulated in any significant way. 

Acetaminophen (N-acetyl-p-aminophenol, APAP, paracetamol, Tylenol®) is a ubiquitous and highly utilized over-the-counter medication for relief of pain and fever that is also a dose-related toxin.1 APAP toxicity accounts for 46% of all acute liver failure (ALF) in the United States2 and between 40 and 70% of all cases in Great Britain and Europe.3 Acetaminophen toxicity dwarfs by several-fold the number of deaths related to acute liver failure (ALF) resulting from all prescription drugs combined (Figure 1), and has been the subject of two United States Food and Drug Administration (FDA) Advisory Committee meetings in the past 15 years.

History

As early as 1960, paracetamol, as it is referred to in Europe and the United Kingdom (UK), had become a popular analgesic for the treatment of headache and mild pain, possessing few of the side effects associated with aspirin (acetylsalicylic acid, ASA). By 1966, reports began to appear concerning its association with liver injury resulting in fatal outcomes. By the 1970's, paracetamol was the most frequently used suicidal agent7 in the UK; the Liver Unit at Kings College Hospital London, in 1972 set up the first 2-bed Liver Failure Intensive Care Unit, typically filled with young women on life support following attempts at self-harm. A single-time-point APAP overdose of 12-15 grams (24-30 ‘extra strength’ (500 mg) tablets), is associated with an approximately 50% mortality.

And for those that weren't around in 1982, it is also the reason why we now have tamper resistant packaging.

https://en.wikipedia.org/wiki/Chicago_Tylenol_murders

Entry #1,104

Remember When...

To everyone complaining about Jimmy Kimmel being canceled and to those saying Trump is censoring him. How soon you forget. During covid do you remember how many people were kicked off twitter and FB (including Trump) and you said they deserved it? Do you remember how many credible researchers, scientists, and medical professionals were shut down, lost their licenses, had accounts canceled for speaking out or for so called misinformation? Do you remember how you cheered about it? How about when you said unvaxxed people should be denied admittance to hospitals even if there was a life threatening condition? Remember that? Remember when you said people without vaccine passports shouldn't be allowed to go out in public? Talk about fascism & dictatorships... Well now it's your turn to FO. How do you like it when it's done to you? If you need a memory refresher on censorship during covid read this.

https://freedomhouse.org/report/report-sub-page/2020/information-isolation-censoring-covid-19-outbreak

Entry #1,100

Public Service Announcement

People, PLEASE put your phones away and pay attention to your surroundings at ALL times. It may save your life or the life of the person next to you.

Entry #1,093
Page 15 of 88
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